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Ritonavir or lopinavir/ritonavir considerably improve plasma concentrations of oxycodone in healthful human volunteers due to inhibition of CYP3A4 and CYP2D6.[58] Rifampicin enormously lowers plasma concentrations of oxycodone as a result of sturdy induction of CYP3A4.Opioids for instance oxycodone hydrochloride may well influence the hypothalamic-

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